Pregnancy eating habits and risk of tumor appearance in descendants in children and adolescents
Keywords:cancer, leukemia, pregnant, infant, nutrition
Proper nutrition is generally defined as a diet that includes all food groups in balanced amounts. The Mediterranean diet is considered to be the standard diet, which seems to equip the human body with the necessary elements to prevent diseases. The present review included 46 surveys conducted during the period from 1995-2005. Research shows that nutrition plays an important role in pregnancy, as inadequate or excessive food intake has been associated with long-term and non-communicable diseases in the offspring. This literature review focuses on the role the diet followed by women during pregnancy plays and especially on the data related to its association with the occurrence of cancer in the offspring. The data highlight the diet of pregnant women as a potential factor in the occurrence of various types of infant or childhood cancer. In particular, micro and macro elements, such as carotenoids, caffeine, folic acid, vitamin C seem to have effects on the fetus when consumed by pregnant women and are involved in epigenetic processes. In conclusion, the advantages and limitations of the various studies were identified, as well as points that need further research.
Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean Diet and Survival in a Greek Population. New England Journal of Medicine. 2003;348(26).
Luyckx V, Perico N, Somaschini M, Manfellotto D, Valensise H, Cetin I, et al. A developmental approach to the prevention of hypertension and kidney disease: a report from the Low Birth Weight and Nephron Number Working Group. Vol. 390, The Lancet. 2017.
Locasale JW. Serine, glycine and one-carbon units: Cancer metabolism in full circle. Vol. 13, Nature Reviews Cancer. 2013.
Lim U, Song MA. Dietary and lifestyle factors of DNA methylation. Vol. 863, Methods in Molecular Biology. 2012.
Wisehart Lindsay. Health Effects of a Vegan Diet and Pediatric Cancer Prevention. 2019.
Jensen CD, Block G, Buffler P, Ma X, Selvin S, Month S. Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States). Cancer Causes & Control 2004 15:6 [Internet]. 2004 Aug [cited 2022 Apr 10];15(6):559–70. Available from: https://link.springer.com/article/10.1023/B:CACO.0000036161.98734.17
Parkin DM, Stiller CA, Draper GJ, Bieber CA. The international incidence of childhood cancer. International Journal of Cancer. 1988;42(4).
Davoodi H, Esmaeili S, Mortazavian AM. Effects of milk and milk products consumption on cancer: A review. Comprehensive Reviews in Food Science and Food Safety. 2013;12(3).
O’Neill B. A scientific review of the reported effects of vegan nutrition on the occurrence and prevalence of cancer and cardiovascular disease. Vol. 3, Bioscience Horizons. 2010.
Campbell TC. Cancer Prevention and Treatment by Wholistic Nutrition. J Nat Sci. 2017;3(10).
Gale KB, Ford AM, Repp R, Borkhardt A, Keller C, Eden OB, et al. Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots. Proc Natl Acad Sci U S A. 1997;94(25).
Hjalgrim LL, Madsen HO, Melbye M, Jørgensen P, Christiansen M, Andersen MT, et al. Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia. British Journal of Cancer. 2002;87(9).
Cnattingius S, Ekbom A, Adami HO, Zack M, Gunnarskog J, Linet M, et al. Prenatal and Neonatal Risk Factors for Childhood Myeloid Leukemia. Cancer Epidemiology Biomarkers and Prevention. 1995;4(5).
Okcu MF, Goodman KJ, Carozza SE, Weiss NS, Burau KD, Bleyer WA, et al. Birth weight, ethnicity, and occurrence of cancer in children: A population-based, incident case-control study in the State of Texas, USA. Cancer Causes and Control. 2002;13(7).
Kaye SA, Robison LL, Smithson WA, Gunderson P, King FL, Neglia JP. Maternal reproductive history and birth characteristics in childhood acute lymphoblastic leukemia. Cancer. 1991;68(6).
Savitz DA, Ananth C v. Birth characteristics of childhood cancer cases, controls, and their siblings. Pediatric Hematology and Oncology. 1994;11(6).
Lagiou P, Mucci L, Tamimi R, Kuper H, Lagiou A, Hsieh CC, et al. Micronutrient intake during pregnancy in relation to birth size. European Journal of Nutrition. 2005;44(1).
Garmendia Madariaga A, Santos Palacios S, Guillén-Grima F, Galofré JC. The incidence and prevalence of thyroid dysfunction in Europe: a meta-analysis. J Clin Endocrinol Metab. 2014 Mar;99(3):923-31. doi: 10.1210/jc.2013-2409. Epub 2014 Jan 1. PMID: 24423323.
Cortes JE, Kantarjian HM. Acute lymphoblastic leukemia a comprehensive review with emphasis on biology and therapy. Vol. 76, Cancer. 1995.
Ernst P, Wang J, Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Vol. 9, Current Opinion in Hematology. 2002.
Vollset SE, Clarke R, Lewington S, Ebbing M, Halsey J, Lonn E, et al. Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Lancet [Internet]. 2013 [cited 2022 Apr 10];381(9871):1029–36. Available from: https://pubmed.ncbi.nlm.nih.gov/23352552/
Petridou E, Ntouvelis E, Dessypris N, Terzidis A, Trichopoulos D, Moschovi M, et al. Maternal diet and acute lymphoblastic leukemia in young children. Cancer Epidemiology Biomarkers and Prevention. 2005;14(8).
Kwan ML, Jensen CD, Block G, Hudes ML, Chu LW, Buffler PA. Maternal diet and risk of childhood acute lymphoblastic leukemia. Public Health Reports. 2009;124(4).
Blot WJ, Henderson BE, Boice JD. Childhood cancer in relation to cured meat intake: Review of the epidemiological evidence. Vol. 34, Nutrition and Cancer. 1999.
Ross JA, Potter JD, Reaman GH, Pendergrass TW, Robison LL. Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): Report from the Children’s cancer group. Cancer Causes and Control. 1996;7(6).
Sarasua S, Savitz DA. Cured and broiled meat consumption in relation to childhood cancer: Denver, Colorado (United States). Cancer Causes & Control. 1994;5(2).
Ivankovic S, Preussmann R, Schmaehl D, Zeller JW. Prevention by ascorbic acid of in vivo formation of N nitroso compounds. IARC (International Agency for Research on Cancer) Scientific Publications. 1974;vol 9.
Menegaux F, Steffen C, Bellec S, Baruchel A, Lescoeur B, Leverger G, et al. Maternal coffee and alcohol consumption during pregnancy, parental smoking and risk of childhood acute leukaemia. Cancer Detection and Prevention. 2005;29(6).
Bonaventure A, Rudant J, Goujon-Bellec S, Orsi L, Leverger G, Baruchel A, et al. Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorphisms. Cancer Causes and Control. 2013;24(4).
Thomopoulos TP, Ntouvelis E, Diamantaras AA, Tzanoudaki M, Baka M, Hatzipantelis E, et al. Maternal and childhood consumption of coffee, tea and cola beverages in association with childhood leukemia: A meta-analysis. Vol. 39, Cancer Epidemiology. 2015.
Milne E, Royle JA, Bennett LC, de Klerk NH, Bailey HD, Bower C, et al. Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: Results from an Australian case-control study. Cancer Causes and Control. 2011;22(2).
Spector LG, Xie Y, Robison LL, Heerema NA, Hilden JM, Lange B, Felix CA, DaviesSM, Slavin J, Potter JD, Blair CK, Reaman GH, Ross JA (Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor) Cancer Epidemiol Biomarkers Prev. 2015 Mar; 14(3):651-5
Astley SB, Elliott RM, Archer DB, Southon S. Increased cellular carotenoid levels reduce the persistence of DNA single-strand breaks after oxidative challenge. Nutrition and Cancer. 2002;43(2).
Collins AR, Harrington V, Drew J, Melvin R. Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis. 2003;24(3).
Fillion L, Collins A, Southon S. Beta-carotene enhances the recovery of lymphocytes from oxidative DNA . Acta BiochimicaPolonica . 1998;183–90.
Torbergsen AC, Collins AR. Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect. European Journal of Nutrition. 2000;39(2).
Wolterbeek APM, Roggeband R, van Moorsel CJA, Baan RA, Koeman JH, Feron VJ, et al. Vitamin A and β-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture. Cancer Letters. 1995 May;91(2):205–14.
Piccoli GB, Clari R, Vigotti FN, Leone F, Attini R, Cabiddu G, et al. Vegan-vegetarian diets in pregnancy: Danger or panacea? A systematic narrative review. Vol. 122, BJOG: An International Journal of Obstetrics and Gynaecology. 2015.
Pawlak R. To vegan or not to vegan when pregnant, lactating or feeding young children. Vol. 71, European Journal of Clinical Nutrition. 2017.
Parisi F, di Bartolo I, Savasi VM, Cetin I. Micronutrient supplementation in pregnancy: Who, what and how much? Vol. 12, Obstetric Medicine. 2019
Cetin I, Berti C, Calabrese S. Role of micronutrients in the periconceptional period. Vol. 16, Human Reproduction Update. 2009.
Fekete K, Berti C, Cetin I, Hermoso M, Koletzko B v., Decsi T. Perinatal folate supply: Relevance in health outcome parameters. Maternal and Child Nutrition. 2010;6(SUPPL. 2).
Thompson JR, Gerald PF, Willoughby MLN, Armstrong BK. Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: A case-control study. Lancet. 2001;358(9297).
Smith ER, Shankar AH, Wu LSF, Aboud S, Adu-Afarwuah S, Ali H, et al. Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries. The Lancet Global Health. 2017;5(11).
King JC. Physiology of pregnancy and nutrient metabolism. In: American Journal of Clinical Nutrition. 2000
Shu XO, Gao YT, Tu JT, Zheng W, Brinton LA, Linet MS, et al. A population‐based case‐control study of childhood leukemia in shanghai. Cancer. 1988;62(3).