Precocious menarche in a 9 years old girl due to autonomous ovarian cyst treated with letrozole

https://doi.org/10.54088/0er03

Authors

  • Elpis Vlachoapapadopoulou Children's Hospital P. & A. Kyriakou
  • Anatoli Fotiadou 2nd Department of Paediatrics, University of Athens, P. & A. Kyriakou” Children's Hospital
  • Martha Moisidou ) Department of Endocrinology, Growth and Development, “P. & A. Kyriakou” Children's Hospital,
  • Fani Athanasouli ) Department of Endocrinology, Growth and Development, “P. & A. Kyriakou” Children's Hospital,
  • Eirini Dikaiakou Department of Endocrinology, Growth and Development, “P. & A. Kyriakou” Children's Hospital,
  • Marina Vakaki Division of Radiology, “P.& Α. Kyriakou” Children’s Hospital, Athens, Greece
  • Lina Michala 1st Dept. Obstetrics and Gynecology, National and Kapodistrian University of Athens, Alexandra General Hospital, Greece
  • Stefanos Michalacos Department of Endocrinology, Growth and Development, “P. & A. Kyriakou” Children's Hospital,

Keywords:

pubertal development, precocious puberty, precocious menarche, ovarian cyst, letrozole

Abstract

Background: Peripheral precocious puberty (PPP) is defined as the early pubertal maturation independent of gonadotropin stimulation. Autonomous ovarian cysts can be a cause of PPP or isolated precocious menarche. The differential diagnosis of ovarian cysts is important because of distinct management options.

Case: A 9 7/12-year-old girl presented because of rapid evolution of breast development and premature menarche. Estrogen levels were elevated while GnRH stimulation test revealed a blunt response. Pelvic sonogram demonstrated an ovarian cyst. She was started on oral letrozole. There was no further episode of menstruation. The cyst resolved spontaneously after three months.

Summary and Conclusion:  Functional ovarian cysts usually regress spontaneously. This case highlights the effectiveness of letrozole therapy in promptly decreasing estrogen levels and immediately controlling menstrual bleeding

References

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Published

2021-07-29

Issue

Vol. 1 No. 3 (2021): DAH March- August 2021

Section

Case report